Modeling oncogene addiction using RNA interference
نویسندگان
چکیده
منابع مشابه
Modeling oncogene addiction using RNA interference.
The clinical efficacy of selective kinase inhibitors suggests that some cancer cells may become dependent on a single oncogene for survival. RNAi has been increasingly used to understand such "oncogene addiction" and validate new therapeutic targets. However, RNAi approaches suffer from significant off-target effects that limit their utility. Here, we combine carefully titrated lentiviral-media...
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to begin with and be bloody-minded about continuing this specific interest. You should always enjoy biology, even when some aspects of doing research are tedious or even unsuccessful. If you don’t enjoy what you are doing, then you might as well be in business and be paid well to do boring things! Beyond that it is a matter of personal style; my advice depends upon where you are on the personal...
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An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo. In several published experiments, RNAi has been used to inactivate components of the RNAi pathway itself, a procedure termed recursive RNAi in this report. The theoretical basis of recursive RN...
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pathways control all phases of tumor development and are critical in cancer therapy as they are largely responsible for the ability of tumor cells to survive or die in response to chemotherapy and radiotherapy. The p38 MAPK signaling pathway is one of the routes that cells use extensively to interpret extracellular signals and orchestrate appropriate responses. This pathway was originally chara...
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tissue is accomplished by removal of keratinocytes harboring HPV. These are the conventional approaches for treatment of cervical cancer. Prophylactic vaccines are available and should be administered prior to viral exposure. Initiatives for vaccination have been undertaken by the governments and also non-governmental agencies. Attempts are being made to develop therapeutic vaccines that would ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0803217105